A series of cinchophen analogues of 2-(naphtha [2, 1-] furan-2-yl) quinoline-4-carboxylic acid 5(a-d) were synthesized by Pfitzinger method and further carboxylates of the corresponding acid 5(a-b) were synthesized by using different alcohols. The structure of synthesized compounds was confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis and were screened for antitubercular activity on Mycobacterium tuberculi (Mtb) H37Rv strain, by Microplate Alamar Blue Assay (MABA) and their antibacterial activity by agar well diffusion method. In-silico molecular docking study was carried out on Auto Dock Vina. The antitubercular activity revealed that compounds 5b, 5d, 6a and 8a exhibited very good activity against M. tuberculi. The antibacterial activity results revealed that compounds 5d were found to be effective against Bacillus subtilus, Paracoccus denitrificans, Staphylococcus aureu sand Paracoccus sp. whereas, the compounds, 5a, 5b, 5d and 6b showed good activity against Paracoccus sp. The in-silico molecular docking studies were carried out on Mycobacterium translation initiation complex subunit S1 with the molecules 5a, 5b, 5c, 5d, 6a, 6b and 8a to identify the best docked conformation against the ribosomal protein S1. The synthesized compounds were found to exhibit good degree of antitubercular and antibacterial activity, this might be because of easy penetration of analogs into the cell membrane.
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